無標題文件
Cancer has become the most common cause of death in Taiwan since 1982. Cancer research is important not only as an academic interest in medical society, but also has heavy impact on our economy and society. To meet the increasing needs for cancer treatment and the further study of endemic cancer, Cancer Research Center of Medical College, National Taiwan University was established on Aug. 18, 1999. The center contains more than 40 physicians and scientists research all aspects of cancer biology. Aside from the Director, the center consists of 1) Division of Medical Oncology 2) Division of radiation Oncology 3) Core Laboratory 4) Clinical Research Laboratory 5) Radiation Biology Laboratory 6) Epidemiology and Biostatistic Laboratory 7) Out-patient Clinical and Chemotherapy Day Care Center and In-patient Ward (135 beds). The goal is to integrate research resources of the cancer treatment in the whole university and to conquer the most important disease in the 21st century. Cancer Research Center has outstanding integrated programs in patient care, basic research, clinical service, medical education, clinical trials, and cancer prevention. These programs include physicians, scientists, nurses, and other health care professionals who provide individualized treatment for patients. More than 100,000 cancer patients visit outpatient clinics each year. All cancer patients receive psychosocial and educational support and help in dealing with their illnesses from the staff and the cancer support program. Cancer Research Center systemically promotes basic and clinical research in oncology, trains of medical and research specialties in oncology, provides highest standard of multi-modality treatment for cancer patients, and campaigns for cancer prevention and treatment.
The short-term goal of Cancer Research Center is to improve cancer patient care based on current facilities in Department of Oncology at National Taiwan University Hospital using existing resources. Midterm to long-term goal is to establish satellite cancer clinics and centers to establish patient referral network. It includes the National Taiwan University Cancer Center. Ranked as the nation’s top cancer center, National Taiwan University Hospital, Cancer Center, and National Taiwan University will earn the trust and respect of all citizens in Taiwan.

In early 1980s, professor Ruey-Lou Sung proposed the idea of organizing a “Cancer Center” in this hospital. In 1991, superintendent Kuo-Hsin Lin approved the formation of “Cancer Research Center”. This was supported by the Dean of Medical College, professor Po-Tsao Huang. A task force Team was appointed for such purpose. The team members included Dr. Sho-Wen Ho,(pathology), Chiu-Hwa Wang(hematology), Prof. Mao-Ming Shu(ENT), Chang-Yao Hsieh(gyn-Obs), Yao-Chang Chen(hematology), Ann-Lii Cheng(oncology), and other doctors who were involved in the clinical care and research of cancer. In 1993 with some of the funding for the formation of National Health Research Institute from the government (Department of Health)and the budget from the hospital, the “Core Research Laboratory” was formed for the purposed of cancer research. In 1993, the Department of Oncology was formed officially. The 6A floor in the East Building was tentatively used as patient ward. Professor Hsieh who was then vice-superintendent of the hospital, was appointed as the chairman. After 1994, the patient ward and outpatients clinic were moved to 5W1/5W2/5W3/5E1 floors of the west Building. Patient ward 4W2 and 6E2 floors of the West Building were moved to the Department of Oncology in July, 2008 and September, 2010, respectively. There are five patient wards with total 135 beds. In 2001, the Division of Radiation Oncology was incorporated into the Department of Oncology. Multi -disciplinary, patient –centered care of cancer patients is offered to the general population. For the technique of radiation oncology, intensity-modulated radiation therapy(IMRT)was introduced in 2002. Image-guided radiation therapy(IGRT)which make radiation therapy more precise was introduced in 2006. Tomotherapy and Volumetric modulated arc therapy(VMAT)were also introduced in 2008 and 2010, respectively. Improvement of efficacy and accuracy of simulation by renewing computed tomography and 4D-CT image scan was done in 2012. Quality of life and treatment efficacy were improved by above techniques.
The comprehensive cancer center was set up earliest in domestic university hospitals. It collects multi-department specialists for the diagnosis and treatment of cancer patients and provides an efficient, high-quality humane medical treatment plan set. Uphold the concept of pluralism team treatment ﹝multi-modality treatment﹞, we establish an integrated outpatient, for people to provide high-quality, full range of humane cancer care. We set up interdisciplinary "lung cancer" and "breast cancer" special clinics during the same period. It invites physician, surgeon, radio-oncologist, and pathologist to make the diagnosis and treatment plan of cancer patients and provide multiple strategies of cancer treatment. In recent years, the center promotes the clinical case managers' care system: the integration of the medical sector, nursing end, the administrative end, and the medical side of the operation by case manager. It makes the patient has a systemic planning and tracking since the onset of disease to the series of treatment and allows the full range of humane care more complete. This mechanism has been expanded to hospital-wide cancer patient since 2011. The center provides standard operating procedures manual (the medical oncology manual), and has regular meetings at ministerial meetings for improvement of quality of care. In 2011, the center services outpatient 108,651 people, the outpatient chemotherapy 44,403 people, 5,027 people hospitalized, and radiation treatment to 58,890 people.

Hospital palliative care ward was set up in June 1995 to improve hospital-wide doctor-patient communication and palliative medical care for cancer patients. In 2005, we joined the plan promoted by Department of Health, Bureau for combined hospice care in non-hospice wards and establishment of palliative care training guideline. According to the different needs, the development of curriculum and promotion including:
1. Encourage the relevant divisions physicians join into palliative medical specialist training.
2. Participate or apply the training or certification for the full-time palliative health care workers, spiritual caregivers, social workers, volunteers, and psychologists.
3. Establish a hospital-wide hospice combined care group to handle non-palliative ward staff education and training and to make them have the ability to provide hospice and palliative care. Make the percentage of terminally ill cancer patients each year who have received hospice care, from 30% to at least 50% by the end of December 31, 2007.
4. To promote the education programs of hospice and palliative care to enhance the non-medical staff, medical students, other patients and their families, and general public.
The center actively involves in the local basic and clinical research of common cancers, such as stomach cancer, liver cancer, stomach lymphoma, and nasopharyngeal carcinoma and the results is fruitful. The strategy of the department is to improve clinical treatment by the results of basic research and resolve the clinical problems by basic research design. Meanwhile, we actively introduce new treatment modalities ﹝such as molecular therapy, photodynamic therapy, gene therapy, immunotherapy, and new technique of radiation therapy﹞ to provide cancer patients more treatment options, enhance the efficacy, and reduce side effects.
The basic research carried out by the core laboratory, equipped with the perfect laboratory equipment and instruments. Ongoing studies include: the translational researches of lung cancer, hepatocellular carcinoma, gastric cancer, gastric lymphoma, nasopharyngeal cancer, cervical cancer, breast cancer, and colorectal cancer, especially the new targeted drugs, living in a global dominance. By rigorous clinical trials to prove drug's efficacy and integration of surgery, radiation therapy, medical oncology, and other experts, to provide multiple strategies of cancer treatment new benchmark. Epidemiological research and statistics offices are committed to the creation of a database of local cancer and epidemiological genomic cancer studies, and to explore the interaction between common cancer in Taiwan and genetic and environmental carcinogens. Ongoing or completed clinical trials, including early (phase I/II, toxicity and pharmacokinetic studies), large-scale, multi-center, randomized clinical trials, and other academic research are more than a total of 80 items. For example, in 2011, we have published a total of 76 SCI papers and provided important basic and clinical research conclusions. In the future, we aim to train more physician scientists with leadership and other clinical trial expertise to strengthen basic studies and clinical trials of cancer and to enhance local common cancer studies.

James Chih-Hsin Yang, Dec. 2012
Teacher
Position
Degree
Field
James Chih-Hsin Yang
Professor
PHD
Medical oncology
Anni-Lii Cheng
Professor
PHD
Medical oncology
Ruey-Long Hong
Clinical professor
PHD
Medical oncology
Ming-Jium Hsieh
Professor
PHD
Digestive tumors, tumor ultrasound
Kun-Huei Yeh
Associate professor
PHD
Medical oncology
Chia-Hsien Cheng
Associate professor
PHD
Radiation oncology
Chin-Hung Hsu
Clinical associate professor
PHD
Medical oncology
Ling Hung Wei
Clinical associate professor
PHD
Gynecologic oncology
Chiun Hsu
Clinical associate professor
PHD
Medical oncology
Yen-Shen Lu
Clinical assistant professor
PHD
Medical oncology
Sung-Hsin Kuo
Clinical assistant professor
PHD
Medical oncology, radiation oncology
Chia-Chi Lin
Clinical assistant professor
PHD
Medical oncology
Ching-Hung Lin
Clinical assistant professor
PHD
Medical oncology
Zong-Zhe Lin
Adjunct assistant professor
PHD
Medical oncology
Ming-Kuen Lai
Adjunct professor
PHD
Urologic oncology
Whang-Pen Jacqueline
Professor
1. Grand round, morbidity and mortality conference, chemotherapy case conference, radiation case conference, combined conference, morning meeting, intern seminar and research meeting are regularly held to promote the quality of patient care and to strengthen the knowledge of medical personnel.
2. Our center aggressively participates in many multicenter international clinical trials and introduces new anticancer drugs to Taiwan. All of the clinical trials strictly follow the Good Clinical Practice (GCP) guidelines. Through regular clinical trial meeting and education, the investigators and research nurses are assured to perform the high-standard clinical trials.
3. Following the policy of Bureau of Health Promotion, we regularly hold combined conferences for 6 endemic cancers in Taiwan. Through the conference, opinions from different specialties are integrated to establish the treatment consensus.
4. The basic research conference and journal discussion provide communication platform between basic science and clinical research. Through vigorous discussion between basic scientists and clinical experts, we have come up with many translational research ideas.
5. Dedicated to cancer prevention, our Cancer Epidemiology Research unit is actively conducting molecular epidemiologic and screening efficacy evaluation studies on liver cancer, cervical cancer and nasopharyngeal carcinoma.
Curriculum planning
1. Our teaching emphasizes the multidisciplinary property and the team work treatment philosophy in modern oncology. In contrast to the traditional “longitudinal “ medical education (divided as internal medicine, surgery, gynecology, pediatrics etc.), our unique “horizontal” teaching style is based on the whole picture of each cancer. For example, a number of our clinics are multidisciplinary, so that physicians from several disciplines, such as medical oncology, surgical oncology and radiation oncology, evaluate the patients together.
2. The Cancer Research Center provides the training platform for oncology fellows, residents, interns, clerks, research nurses and oncology nurses. All of them are expected to aggressively participate in primary care and treatment planning for the cancer patients. Thus they will learn from different specialists and play an important role in this team work. For fellows, our training program includes an extensive clinical practice and research opportunities including basic science and clinical research. Every year, 3-5 medical oncology fellows and 1-3 radiation oncology fellows will finish their subspecialty training.
3. Our clinical researches focus on developing new treatments for endemic cancers in Taiwan, including gastric cancer, nasopharyngeal cancer, liver cancer etc. The major approach is through the clinical trials and the study treatments focus on molecular targeted therapy, anti-angiogenesis therapy and combined multi-modality treatment. Through the cooperation with global pharmaceutical and biotechnology companies, we hope to build the most important clinical trial center in Asia.
4. Our basic researches focus on relationship of microorganism and oncogenesis, drug resistance and its reversal, and development of novel molecular targeted therapy and antiangiogenesis therapies for endemic cancers. Through interaction of basic science and clinical medicine, researchers and physicians will be expected to move basic research findings expeditiously from the laboratory bench to the bedside. Our goal is to build the best translational center in Asia.
   
 
Professor:James Chih-Hsin Yang
Tel:+886-2-23123456 67511
Fax:
E-mail:chihyang@ntu.edu.tw
 


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