The institute established with the objectives to train toxicology professionals for academia, industry, and government institutions, to promote toxicological teaching, research and service, and to improve public health.
The institute established its M.S. and Ph.D. programs in toxicology in 1990 and 1993, respectively.
Director/ Associate Professor
Focus on the nanotoxicogenomics, novel target therapy for anti-cancer, and reproductive medicine, Dr. Chen’s research emphasizes the use of genomic approaches in the study of toxicity and applications of new nanomaterials; the study of novel compounds in anti-cancer metastasis; the genetic/epigenetic regulating mechanisms in cancer stem cells and pre-implantation embryo development.
Cellular signal transduction in toxicology; enviromental toxicants and disabetes; cellular and molecular mechanisms of disabates-related organopathy.
Genetic and molecular toxicology; effects of carcinogens and toxic substances on cells and genes; molecular mechanism of anticarcinogenicity of natural compounds.
Cellular and molecular toxicology; effects of chemicals and drugs on receptors and enzymes of plasma membranes; roles of calcium in chemically induced cytotoxicity.
-Studying the molecular and toxicological mechanisms of natural toxins, including mycotoxins and phytotoxins, by using cellular and zebrafish models
-Establishing immunochemical methods for the detection of natural toxins in environmental samples, including food, feed and water.
Mycotoxicology and regulatory toxicology; metabolism, mechanism of action, and structure-activity relationship of territrems; control and regulation of toxic substances.
Toxicological teaching, research, and service require adequate faculty, funds, and facilities. The faculty of the institute consists of five professors and associate professors. The faculty members are conduction research in the areas of biochemical and molecular toxicology, genetic toxicology, immunotoxicology, neurotoxicology, and environmental toxicology. These research programs are funded by twelve grants from the National Science Council, Administration of Health, and Environmental Protection Administration with a sum exceeding ten million NT dollars. The institute has published more than eighty papers and abstracts in local and international scientific journals and meetings in the past three years. The institute is well equipped and has free access to the Instrument Center, Animal Center, and other facilities provided in the College of Medicine. The institute also collaborates with toxicological researchers who research in different locations throughout the college and in other institutions.
Toxicology is a discipline that combines the principles of biology and chemistry to investigate the underlying mechanisms responsible for the adverse effects on biological systems and to assess the probability of risk. The main results of toxicology studies will provide better understanding and help create preventive and therapeutic measures of acute and chronic toxicities associated with toxic substances of natural and artificial origins. The toxicological research activities include investigation of mechanism of toxicity; evaluation, screening and prevention of toxicity; description of carcinogenicity and teratogenicity; and characterization of metabolic, morphological, and physiological abnormalities. The recurring incidents of environmental pollution, drug abuse, and food poisoning strongly emphasize the need for an accelerated development of toxicological research to contribute in maintaining the public health and economic growth of the society.
Now the institute has 20 Ph.D. and 21 M.S. students. The M.S. program requires at least 24 credits of course work, in addition to a thesis. Upon completion of course work and passing an oral examination in defense of the thesis, a M.S. degree is conferred. A student is required to complete the graduate program in 1 to 4 years. The Ph. D. program requires at least 18 credits of course work, in addition to a thesis. Upon completion of course work and passing a qualify exam and an oral examination in defense of the thesis, a Ph.D. degree is conferred. A student is required to complete the graduate program in 2 to 7 years.
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